Selank

▸ Overview

Selank is a synthetic heptapeptide based on endogenous tuftsin, with anxiolytic, immunomodulatory and nootropic properties. It is investigated for its action on the GABAergic system and its ability to reduce anxiety without sedation or dependence.

▸ Mechanism of action

• A synthetic heptapeptide based on endogenous tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro extension for greater stability.
• Modulates the GABAergic system, enhancing neuronal inhibition similarly to the anxiolytic effect of benzodiazepines but without sedation or dependence.
• Upregulates the expression of genes related to the innate immune system, with documented immunomodulatory effects.
• Inhibits the breakdown of enkephalins (endogenous opioids), prolonging their natural anxiolytic and analgesic effects.
• Modulates serotonin and interleukin-6 production, contributing to its mood-stabilizing effect.
• Improves working memory and concentration without the stimulant effects of classic psychostimulants.
• Approved in Russia for treating anxiety disorders and as a clinical nootropic.

▸ Administration

• Intranasal route: drops or nasal spray; the most used form in research.
• Subcutaneous route: an alternative for greater systemic bioavailability.
• Storage: refrigerate at 2–8 °C; protect from light.

▸ Timing

• No strict fasting restrictions.
• Can be administered during moments of high cognitive demand or stress.
• The intranasal route produces relatively fast effects (15–30 minutes).

▸ Dosing & cycles

• Cycles: 10–14 continuous days is the most studied schedule, followed by a break.
• Can be used in short cycles or as intermittent use.
• Combined with Semax in 2-weeks-on / 2-weeks-off cycles.

▸ Combinations

• Selank + Semax: the classic nootropic synergy for cognition and anxiety.
• Can be combined with Epitalon in anti-aging protocols.
• Investigated alongside recovery peptides in general-wellbeing protocols.

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