Epitalon

▸ Overview

Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epitalamin, an extract of the pineal gland. It is investigated for its ability to activate telomerase, lengthen telomeres and modulate the circadian rhythm. It is considered one of the most promising anti-aging peptides.

▸ Mechanism of action

• A synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epitalamin, an extract of the bovine pineal gland.
• Activates telomerase (the enzyme that lengthens telomeres), partially reversing the telomere shortening associated with cellular aging.
• Studies in human cells show an extension of replicative lifespan of more than 10 additional cycles.
• Regulates melatonin production by the pineal gland, normalizing circadian rhythms in older people.
• Modulates the expression of aging-related genes: reduces the expression of p16 and p21 (senescence markers).
• Has antioxidant effects: reduces cellular oxidative stress and lipid-peroxidation markers.
• Studies in rodents show a 24% extension of maximum lifespan and a reduction in spontaneous tumor incidence.

▸ Administration

• Subcutaneous or intravenous route: both used in research.
• Reconstitution: lyophilized powder with bacteriostatic water.
• Storage: refrigerate at 2–8 °C; temperature-sensitive.

▸ Timing

• No specific fasting restrictions.
• Usually administered in the morning or according to the cycle protocol.
• Some protocols use nighttime administration because of its relationship with melatonin.

▸ Dosing & cycles

• Short intensive cycles: 10–20 days of daily administration, 1–2 times per year.
• Long cycles: lower doses over a longer duration.
• Telomerase activation is the main research mechanism.

▸ Combinations

• Epitalon + Selank: an anti-aging + nootropic combination.
• Investigated alongside recovery and circadian-regulation peptides.
• Sometimes combined with Semax in longevity protocols.

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